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Review ArticleOpen Access

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Chao Yang, Yingying Sun, Yan Zhang, et al.

Jul 14, 2026

Read on Wiley DOI: 10.1002/mdr2.70080

Research ArticleOpen Access

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Bing Zhang, Fen Yang, Xingji Lian, et al.

Jul 6, 2026

Read on Wiley DOI: 10.1002/mdr2.70078

Review ArticleOpen Access

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Yixian Cheng, Junjie Chen, Rui Fu, et al.

Jul 3, 2026

Read on Wiley DOI: 10.1002/mdr2.70079

Review ArticleOpen Access

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Xuanlu Shen, Chunrun Qu, Zeyu Wang, et al.

Jun 26, 2026

Read on Wiley DOI: 10.1002/mdr2.70074

Research ArticleOpen Access

KMT5C‐Mediated H4K20me3 Recruits EWSR1 to Propel Clear Cell Renal Cell Carcinoma Progression via Regulating ACADM Transcription and m6A Modification

Chengjian Ji, Da Zhong, Tian Rao, et al.

Jun 21, 2026

Read on Wiley DOI: 10.1002/mdr2.70065

CorrespondenceOpen Access

Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies

Xu Zhang, Kailai Li, Yasi Zhang, et al.

Jun 18, 2026

Read on Wiley DOI: 10.1002/mdr2.70077

Research ArticleOpen Access

Prioritizing Modifiable Risk Factors for Cardiovascular Diseases in Adults With Hypertension: A Prospective Cohort Study

Shengtao Wei, Dashan Zheng, Lan Chen, et al.

Jun 9, 2026

Read on Wiley DOI: 10.1002/mdr2.70075

CorrespondenceOpen Access

easyGBDR: An Integrated R Toolkit for Comprehensive Secondary Analysis of Global Burden of Disease Database

Yingying Fang, Zeyu Li, Yiming Song, et al.

Jun 3, 2026

Read on Wiley DOI: 10.1002/mdr2.70069

Research ArticleOpen Access

Transforming Musculoskeletal Disorder Management With Multimodal AI Platform for Early Diagnosis, Self‐Screening, and Personalized Care

Pengyuan Xu, Guang Yang, Ge Zhang, et al.

Jun 3, 2026

Read on Wiley DOI: 10.1002/mdr2.70073

Research ArticleOpen Access

Development and Validation of a Questionnaire‐Based Model for Households With Multiple Helicobacter pylori Infections: A Family‐Based Screening Strategy

Yifan Qiu, Xianzhu Zhou, Yi Hu, et al.

May 19, 2026

Read on Wiley DOI: 10.1002/mdr2.70071

Review ArticleOpen Access

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Qingqiang Lei, Xiaoxian Lou, Xu Su, et al.

May 19, 2026

Read on Wiley DOI: 10.1002/mdr2.70072

Review ArticleOpen Access

Deep Learning Unlocks Behavioral Prediction and Neurobehavioral Decoding

Tianzhe Han, Yunhua Jia, Xiaomin Hu, et al.

May 13, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70070

CorrespondenceOpen Access

scMetaTraj: A Metabolism‐Centered Framework for Trajectory Inference in Single‐Cell Data

Jinwei Dai, Zhihong Zuo, Xiaoyang Pang, et al.

May 10, 2026

Read on Wiley DOI: 10.1002/mdr2.70067

CorrespondenceOpen Access

Mapping the Radiopharmaceutical Therapy Landscape for Prostate Cancer: Insights Into Global Clinical Trial Trends and Future Directions

Zhiwu Dong, Sixiang Yan, Xiaodong Liu, et al.

May 6, 2026

Read on Wiley DOI: 10.1002/mdr2.70068

CorrespondenceOpen Access

Single‐Cell Transcriptomics and Deep Learning Link N‐(2‐Furoyl) Glycine to GLRX3 in Gastric Cancer

Yingyi Zhang, Chenchen Wang, Tianliang Liu, et al.

Apr 29, 2026

Read on Wiley DOI: 10.1002/mdr2.70066

Research ArticleOpen Access

Diverging Cervical Cancer Burden in Africa in the Context of WHO's Elimination Strategy: Insights From GBD 2023

Yedong Huang, Shun Chen, Shiqi Ren, et al.

Apr 16, 2026

Read on Wiley DOI: 10.1002/mdr2.70063

Review ArticleOpen Access

Inflammation, Immunity, and Cardiovascular Diseases

Dezhi Guo, Yan Liao, Rui Zhao, et al.

Apr 9, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70064

CorrespondenceOpen Access

GAnnoViz: A Cloud‐Integrated Platform for Chromosome‐Level Feature Annotation and Visualization in Biomedical Multi‐Omics

Benben Miao, Yawei Shen, Hanjiao Luo, et al.

Apr 8, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70062

Review ArticleOpen Access

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Xiaofeng Dai, Mingze Tang

Mar 28, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70060

Review ArticleOpen Access

The Application of Telemedicine in Surgery

Yufan Yang, Chang Liu, Xue Sun, et al.

Mar 25, 2026

Read on Wiley DOI: 10.1002/mdr2.70061

Research ArticleOpen Access

A Data‐Driven Redefinition of Early Relapse in Pediatric T Cell Acute Lymphoblastic Leukemia: Evidence for Progression of Disease 15 Months

Na Zhang, Wenli Tang, Yali Shen, et al.

Mar 22, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70059

CorrespondenceOpen Access

CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine

Jie Yang, Suibi Yang, Jiajun Cai, et al.

Mar 12, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70057

Review ArticleOpen Access

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, et al.

Feb 25, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70056

Research ArticleOpen Access

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Haolong Zhou, Danyang Ling, Qin Huang, et al.

Feb 10, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70055

EditorialOpen Access

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Guohui Xiao, Min Ding, Zhixue Min, et al.

Feb 3, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70050

CorrespondenceOpen Access

Alveolar Fibroblasts Respond to Pseudomonas Aeruginosa Infection With Cytokine Secretion: Role in Acute Lung Inflammation

Yue Zhou, Yangyang Xiao, Wei Liu, et al.

Jan 14, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70053

CorrespondenceOpen Access

The General Disease Factor (“d”): First Empirical Evidence From China

Hongyi Sun, Qinghuan He, Ting Su, et al.

Jan 8, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70054

Review ArticleOpen Access

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Tian Zhang, Ge Zhang, Tian‐Ding Liu, et al.

Jan 5, 2026Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70052

ArticleOpen Access

Advances and Prospects of Stereotactic Radiosurgery and Stereotactic Ablative Body Radiotherapy: Evolving Paradigms in Precision Oncology

Jing Zhang, Wenhao Xu, Weiqing Lu, et al.

Dec 19, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70051

ArticleOpen Access

Tumor Organoids: Breakthroughs in Clinical Decision Making, Drug Development, and Translational Advances Beyond Conventional Models

Yimao Wu, Ruowei Sun, Gokhan Zengin, et al.

Dec 14, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70048

ArticleOpen Access

Preoperative VEGFR‐TKI Plus ICI Therapy Facilitates 3D‐Guided Cytoreductive Nephron‐Sparing Surgical Feasibility and Immune Remodeling in Advanced Renal Cell Carcinoma

Wenhao Xu, Aihetaimujiang Anwaier, Qintao Ge, et al.

Nov 28, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70047

ArticleOpen Access

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, et al.

Nov 17, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70043

ArticleOpen Access

The Global Burden of Leukemia, 1990–2021: A Systematic Analysis of Prevalence, DALYs, and Risk Factors From the Global Burden of Disease Study

Yuping Wu, Haini Zhang, Shuang Luo, et al.

Nov 17, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70036

ArticleOpen Access

Incidence and Mortality Risks of Gastrointestinal Cancers During Working‐Age Period: Trends and Disparities in 204 Countries and Territories (1990–2021)

Yiming Song, Zhongge Ji, Xunbing Zhang, et al.

Nov 14, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70045

EditorialOpen Access

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Xiaohong Ke, Kailai Li, Anqi Lin, et al.

Nov 11, 2025Volume 2 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70046

ArticleOpen Access

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Kailai Li, Peixin Huang, Yue Qian, et al.

Nov 5, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70044

ArticleOpen Access

Beyond Tumor Control: A Protocol for Multidimensional Assessment of Long‐Term Effects of Intensity‐Modulated Radiotherapy on Vision, Patient Well‐Being, and Morbidity in Head and Neck Cancer

Benjamin Abaidoo, Hannah Ayettey, Andrew Elikem Akafo, et al.

Nov 3, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70041

ArticleOpen Access

Large Language Models in Cardiovascular Imaging: Current Applications and Future Prospects

Weifeng Yuan, Rong Xu, Shengkun Peng, et al.

Nov 3, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70042

ArticleOpen Access

Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index

Zhizhan Ni, Pengyuan Zhu, Liming Liu, et al.

Nov 1, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70038

ArticleOpen Access

Cloud‐Based GWAS Platform: An Innovative Solution for Efficient Acquisition and Analysis of Genomic Data

Xiaohong Ke, Kailai Li, Aimin Jiang, et al.

Nov 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70040

ArticleOpen Access

Differential Patterns of Structural and Functional Disruptions of PCN and DMN‐Related Regions: Longitudinal Evidence Reveals Cascading Network Dysregulation Across the AD Continuum

Ruilin Chen, Guiyan Cai, Jingrou Huang, et al.

Oct 28, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70037

ArticleOpen Access

RSA‐KG: A Graph‐Based Rag Enhanced AI Knowledge Graph for Recurrent Spontaneous Abortions Diagnosis and Clinical Decision Support

Yibo He, Yinying Chai, Yonglin Liu, et al.

Oct 28, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70039

ArticleOpen Access

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Minghui Tang, Yuying Mo, Zhishan Ling, et al.

Oct 24, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70029

ArticleOpen Access

Global, Regional, and National Burden and Quality of Care Index (QCI) of Motor Neuron Disease: A Systematic Analysis of the Global Burden of Disease Study 1990 to 2021

Huilin Xia, Ran He, Hong Zhang, et al.

Oct 23, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70034

ArticleOpen Access

Anxiety Disorders Were Major Mental Disorders Among Adolescents and Young Adults in China From 1990 to 2021: Results From the Global Burden of Disease Study 2021

Zenghong Wu, Fangnan Xia, Rui Qian, et al.

Oct 7, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70035

ArticleOpen Access

Global, Regional, and National Burden of Cancer in the Elderly Population, 1990–2021: Analysis of Data From the Global Burden of Disease Study 2021

Xiaohan Zhu, Xinya Che, Ruonan Yang, et al.

Sep 27, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70031

ArticleOpen Access

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

Zhendong Qin, Mingjun Lu, Jingwei Guo, et al.

Sep 24, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70032

ArticleOpen Access

E2E: An R Package for Easy‐to‐Build Ensemble Models

Shanjie Luan, Ximing Wang

Sep 19, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70030

ArticleOpen Access

bregr : An R Package for Streamlined Batch Processing and Visualization of Biomedical Regression Models

Shixiang Wang, Yun Peng, Chenyang Shu, et al.

Sep 17, 2025Volume 2 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70028

ArticleOpen Access

Tumor Necrosis Factor‐ α Induces Human Bronchial Fibroblasts to Produce Cytokines: Implications for Airway Inflammation

Dong Zhang, Wei Liu, Qiuwen Chen, et al.

Aug 31, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70027

ArticleOpen Access

HPV Integration: Moving From Carcinogenesis Mechanisms to Clinical Applications

Shaoyang Lai, He Liu, Tian Chu, et al.

Aug 19, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70026

ArticleOpen Access

Identifying Potential Vulnerability to Long COVID Through Global‐to‐Local Inequalities in Years Lived With Disability Attributed to COVID‐19, 2020–2021, Across 920 Locations

Dan Shan, Wenyi Jin, Fei Li, et al.

Aug 3, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70023

ArticleOpen Access

Effectiveness of Corticosteroid Strategy in Three Community‐Acquired Pneumonia Clinical Phenotypes: A Multicenter Retrospective Cohort Study

Qiangqiang Qin, Qingxuan Li, Jie Zhao, et al.

Aug 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70024

ArticleOpen Access

Exploring the Potential Anticancer Effects of Lobelia chinensis Lour in Liver Cancer via Multiomics Analysis

Zixuan Yang, Li Song, Hongru Chen, et al.

Aug 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70025

ArticleOpen Access

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Anqi Lin, Keyin Zheng, Aimin Jiang, et al.

Jul 29, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70019

ArticleOpen Access

Causal Link and Shared Biomarkers Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis

Xixi Pan, Chunhui Jiang, Jiani Chen, et al.

Jul 25, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70021

ArticleOpen Access

Global Disease Burden of Immune‐Mediated Inflammatory Diseases (IMIDs), 1990–2021

Xueping Zhu, Mengli Yue, Xu Zhang, et al.

Jul 25, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70018

ArticleOpen Access

The Dual Role of Exosomes in the Tumor Microenvironment: From Pro‐Tumorigenic Signaling to Immune Modulation

Jiale Li, Jun Peng, Jiachong Wang, et al.

Jul 25, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70022

ArticleOpen Access

Ferroptosis in Pneumoconiosis: From Molecular and Cellular Mechanisms to Therapeutic Strategies

Mengli Yan, Jing Zhang, Gaili Ji, et al.

Jul 21, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70020

ArticleOpen Access

Harnessing Small‐Data Machine Learning for Transformative Mental Health Forecasting: Towards Precision Psychiatry With Personalised Digital Phenotyping

Peng Wang, Hongjun Liu, Yiming Shi, et al.

Jul 19, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70017

ArticleOpen Access

Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis

Xiumei Tang, Yanyun Pang, Peijia Zhu, et al.

Jul 16, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70016

ArticleOpen Access

Current Application Status and Innovative Development of Surgical Robot

Aimin Jiang, Zhao Tang, Hanzhong Zhang, et al.

Jul 14, 2025Volume 1 · Issue 3

Read on Wiley DOI: 10.1002/mdr2.70014

ArticleOpen Access

rcssci: An R Package for Visualization of Restricted Cubic Spline

Hongbin Xu, Chen Chen, Zu Xun Lu, et al.

Jul 3, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70015

ArticleOpen Access

Global, Regional, National, and Local Burden of COVID‐19 With Inequality Analysis Across 920 Locations, 2020–2021

Dan Shan, Wenyi Jin, Fei Li, et al.

Jun 25, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70013

ArticleOpen Access

Coexistence of APC and KRAS Mutations in Familial Adenomatous Polyposis and Endometrial Cancer: A Mini‐Review With Case‐Based Perspective

Tongchuan Yin, Zhenhua Tan, Lanjin Bai, et al.

Jun 9, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70011

ArticleOpen Access

Comprehensive Multi‐Omics Integration Reveals B Cell‐Derived ELL2 as a Novel Diagnostic and Prognostic Biomarker in Sepsis

Xuan Wang, Jihong Li, Jingyuan Ning

Jun 6, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70010

ArticleOpen Access

DrugtargetMR, an Integrated Software for Identifying Genetic Determinants Underlying Human Complex Traits

Qiong Lyu, Lihaoyun Huang, Gang Liu, et al.

Jun 4, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70008

ArticleOpen Access

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Shan Liu, Danyang Lv, Junran Sun, et al.

Jun 4, 2025Volume 1 · Issue 2

Read on Wiley DOI: 10.1002/mdr2.70009

ArticleOpen Access

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Guoqing Li, Yuxuan Wan, Alan Jiao, et al.

May 22, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70007

ArticleOpen Access

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Zhifei Gao, Aimin Jiang, Zizhuo Li, et al.

May 21, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70006

ArticleOpen Access

Med Research: Building Interdisciplinary Bridges and Leading Global Medical Innovation

Quan Cheng, Peng Luo, Xuanlu Shen, et al.

May 5, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70005

ArticleOpen Access

Optimized Dynamic Network Biomarker Deciphers a High‐Resolution Heterogeneity Within Thyroid Cancer Molecular Subtypes

Haonan Zhang, Ge Zhang, Pengyuan Xu, et al.

Apr 29, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70004

ArticleOpen Access

Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation

Qiang Li, Hengrui Liu, Jiayan Jin, et al.

Apr 18, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70002

ArticleOpen Access

Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma

Qing Ji, Chunwei Xu, Qian Wang, et al.

Apr 17, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70003

ArticleOpen Access

GseaVis: An R Package for Enhanced Visualization of Gene Set Enrichment Analysis in Biomedicine

Jun Zhang, Hongyuan Li, Wenjun Tao, et al.

Mar 31, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70000

ArticleOpen Access

Systematic Investigation of Tumor Microenvironment and Antitumor Immunity With IOBR

Yiran Fang, Yuyun Kong, Guangda Rong, et al.

Mar 26, 2025Volume 1 · Issue 1

Read on Wiley DOI: 10.1002/mdr2.70001

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